Authors: Nachshon Korem; Or Duek; Ziv Ben-Zion; Antonia N. Kaczkurkin; Shmuel Lissek; Temidayo Orederu; Daniela Schiller; Ilan Harpaz-Rotem; Ifat Levy · Research

How Does PTSD Affect Pain Processing in the Brain?

Research reveals how PTSD changes pain processing in the brain and its connection to emotional numbing symptoms

Source: Korem, N., Duek, O., Ben-Zion, Z., Kaczkurkin, A. N., Lissek, S., Orederu, T., Schiller, D., Harpaz-Rotem, I., & Levy, I. (2022). Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology, 47(11), 1913-1921. https://doi.org/10.1038/s41386-022-01405-2

What you need to know

  • People with PTSD show reduced brain activity in the amygdala when experiencing mild pain compared to veterans without PTSD
  • Lower amygdala activity is linked to more severe emotional numbing symptoms in PTSD
  • This finding suggests emotional numbing and pain processing share common brain mechanisms in PTSD

The Paradox of Pain in PTSD

Have you ever noticed how differently people react to pain? For some, a minor cut feels excruciating, while others barely notice significant injuries. This variation in pain perception becomes even more complex in people with Post-Traumatic Stress Disorder (PTSD). They often show a puzzling pattern - they’re less sensitive to mild pain but react more strongly to severe pain compared to others. Why does this happen?

Understanding Pain Processing in the Brain

Pain isn’t just a physical sensation - it has both physical and emotional components. Two key brain regions play different roles in processing pain:

  • The insula handles the physical aspects of pain (like location and intensity)
  • The amygdala processes the emotional aspects of pain (how unpleasant it feels)

Think of the insula as a pain thermometer that measures intensity, while the amygdala is like an emotional interpreter that decides how much the pain should bother you.

The PTSD Brain Responds Differently

The researchers conducted brain imaging studies on veterans with and without PTSD while administering mild electric shocks. What they found was fascinating: veterans with PTSD showed significantly less amygdala activity in response to mild pain compared to veterans without PTSD. Importantly, this difference was specific to the amygdala - the insula showed similar activity levels in both groups.

The Connection to Emotional Numbing

One of the most striking findings was that lower amygdala activity during pain was strongly linked to emotional numbing symptoms. Emotional numbing, where people have difficulty experiencing feelings, is a common symptom of PTSD. The less the amygdala responded to pain, the more severe the emotional numbing symptoms were.

What This Means for You

If you or someone you know has PTSD, these findings help explain why pain and emotions might feel different:

  • The reduced amygdala response may be your brain’s way of protecting you from overwhelming experiences
  • Being less sensitive to mild pain or emotions isn’t a personal failure - it’s a documented brain response
  • Understanding this connection can help guide treatment approaches that address both pain processing and emotional awareness
  • Mindfulness practices that help you tune into physical and emotional sensations might be particularly beneficial

Conclusions

  • The brain processes pain differently in people with PTSD, specifically showing reduced activity in emotion-processing regions
  • This altered pain processing is closely connected to emotional numbing symptoms
  • Understanding these brain mechanisms can help develop more effective treatments that address both pain perception and emotional awareness
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