Authors: Seyma Katrinli; Anthony P. King; Elizabeth R. Duval; Alicia K. Smith; Nirmala Rajaram; Israel Liberzon; Sheila A. M. Rauch · Research
Can PTSD Treatment Reverse Accelerated Biological Aging?
Study examines whether PTSD treatment can reverse accelerated biological aging in military veterans with combat-related trauma
Source: Katrinli, S., King, A. P., Duval, E. R., Smith, A. K., Rajaram, N., Liberzon, I., & Rauch, S. A. M. (2023). DNA methylation GrimAge acceleration in US military veterans with PTSD. Neuropsychopharmacology, 48, 773-780. https://doi.org/10.1038/s41386-023-01537-z
What you need to know
- People with PTSD show signs of accelerated biological aging compared to those without PTSD
- This accelerated aging can be measured through DNA changes called methylation patterns
- While PTSD treatment helps reduce symptoms, it may not reverse the accelerated aging effects within 24 weeks
The Impact of Trauma on Aging
When we experience severe trauma, it doesn’t just affect our mental health - it can actually change how our bodies age at a biological level. Research is revealing that post-traumatic stress disorder (PTSD) may speed up the aging process in ways we can measure through changes in our DNA. This is particularly concerning for military veterans who have experienced combat trauma.
Understanding Biological Age vs Chronological Age
Scientists can now measure something called “GrimAge” - a biological marker that predicts how quickly someone is aging compared to their actual chronological age. Think of it like two different clocks: your birthday clock (chronological age) and your body’s internal clock (biological age). In people with PTSD, that internal clock often runs faster than expected.
The Research Findings
This study looked at military veterans with combat-related PTSD and compared their biological aging patterns to veterans without PTSD and civilians who hadn’t experienced combat trauma. The researchers found that those with PTSD showed signs of accelerated aging compared to both control groups. This suggests that PTSD itself, rather than just combat exposure, may be driving the faster aging process.
Treatment Effects on Aging
The study then examined whether successful PTSD treatment could slow down or reverse this accelerated aging. While the treatments (including medication and therapy) were effective at reducing PTSD symptoms, they didn’t appear to reverse the accelerated aging patterns within the 24-week study period. This raises important questions about whether longer treatment periods might be needed to affect biological aging.
What This Means for You
If you or someone you know is dealing with PTSD, these findings highlight several important points:
- Getting treatment for PTSD is crucial - it can significantly reduce symptoms even if it doesn’t immediately reverse all biological effects
- The sooner you seek treatment, the better, as PTSD’s effects on aging may accumulate over time
- Taking care of your overall health becomes especially important if you have PTSD
- Future treatments may need to specifically target biological aging alongside PTSD symptoms
Conclusions
- PTSD appears to speed up biological aging processes in the body
- While current treatments help with PTSD symptoms, they may not quickly reverse aging effects
- More research is needed on longer-term treatments and their impact on biological aging
- The findings emphasize the importance of early intervention for PTSD